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<p class="mv-txt01">Our Focus on Immuno-Oncology</p>
<h1 class="mv-ttl01">In the field of immuno-oncology, the STAM™ mouse is the most pathologically suitable model for developing new therapeutic drugs for liver cancer.</h1>
<p class="mv-ttl02">The utilization of STAM™ mouse enables non-clinical research for the development of liver cancer therapeutics targeting immune cells, tumor microenvironment, and genetic mutations.</p>
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<p class="mv-ttl01">【Breaking News!】 First MASH treatment approved by FDA</p>
<p class="mv-ttl02"></p><p>On March 14th, The United States Food and Drug Administration (FDA) announced their approval of Rezdiffra (res…</p>
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<p class="mv-txt01">EVENT</p>
<p class="mv-ttl01">SMC will be exhibiting at The 110th General Meeting of the Japanese Society of Gastroenterology</p>
<p class="mv-ttl02"></p><p>We are pleased to announce that SMC Laboratories will be exhibiting at The 110th General Meeting of the Japane…</p>
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<p class="mv-ttl01">Cell metab.,</p>
<p class="mv-ttl02">“MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity” (Cell Metab., DOI: 10.1016/j.cmet.2022.10.007., 2022)</p>
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<p class="mv-ttl01">STAM™ model</p>
<p class="mv-ttl02">Our STAM™ model is a model that recapitulates the same disease progression as human MASH/HCC.</p>
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<p class="desc">The STAM™ mouse is our in-house developed model. It is a MASH-HCC model with a diabetes background. So far, we have over 15 MOA categories and more than 270 target molecules of test substances that we have evaluated using STAM™ mice.</p>
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<p class="desc01">We are contributing to the world through providing cutting-edge non-clinical pharmacology studies with our unique patented technology, the STAM™ mouse. In order to develop a new drug, it is important to be able to accurately measure the effectiveness of the drug at the non-clinical trial stage. The STAM™ mouse, a model that more accurately reflects human pathology, plays a major role for this purpose.</p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Pitfalls of [ disease model mice ] that researchers unknowingly fall into.</h3></div>
<p class="item-desc"></p><p>In order to evaluate your compound, rather than using a general pulmonary fibrosis model that does not match y…</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/pitfalls-of-disease-model-mice-that-researchers-unknowingly-fall-into/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">| A must for IPF researchers! | Suggestions for the best disease model for your research</h3></div>
<p class="item-desc"></p><p>If you are considering a drug efficacy study using a mouse model of lung fibrosis, you should use a model that…</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/a-must-for-ipf-researchers-suggestions-for-the-best-disease-model-for-your-research/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.04.08</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">【Hot data】 Resmetirom (MGL-3196) evaluation data available in STAM<sup>TM</sup> model</h3></div>
<p class="item-cats"><span class="cat">MASH</span><span class="cat">Resmetirom</span><span class="cat">STAM</span></p>
<p class="item-desc"></p><p>As you may already know, the United States Food and Drug Administration (FDA) announced the approval of Rezdif…</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/%e3%80%90hot-data%e3%80%91-resmetirom-mgl-3196-evaluation-data-available-in-stam-model/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.21</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">What is the best non-clinical liver cancer model with 100% cancer incidence rate and suitable for liver cancer assessment?</h3></div>
<p class="item-desc"></p><p>If you are considering a drug evaluation study for liver cancer using a mouse model, our STAMTM-HCC/IO+ model …</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/what-is-the-best-non-clinical-liver-cancer-model-with-100-cancer-incidence-rate-and-suitable-for-liver-cancer-assessment/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.19</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">[ Breaking News! ] First MASH treatment approved by FDA</h3></div>
<p class="item-desc"></p><p>On March 14th, industry-altering news was published. Do you know already what we are talking about? The United…</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/breaking-news-first-mash-treatment-approved-by-fda/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">[Existing compounds] that have advanced to clinical trials will accelerate the launch of your drugs.</h3></div>
<p class="item-desc"></p><p>If you are planning to launch your therapeutic drug, you should select disease mouse models that have shown ac…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/existing-compounds-that-have-advanced-to-clinical-trials-will-accelerate-the-launch-of-your-drugs/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Pitfalls of [ disease model mice ] that researchers unknowingly fall into.</h3></div>
<p class="item-desc"></p><p>In order to evaluate your compound, rather than using a general pulmonary fibrosis model that does not match y…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/pitfalls-of-disease-model-mice-that-researchers-unknowingly-fall-into/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">| A must for IPF researchers! | Suggestions for the best disease model for your research</h3></div>
<p class="item-desc"></p><p>If you are considering a drug efficacy study using a mouse model of lung fibrosis, you should use a model that…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/a-must-for-ipf-researchers-suggestions-for-the-best-disease-model-for-your-research/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.04.08</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">【Hot data】 Resmetirom (MGL-3196) evaluation data available in STAM<sup>TM</sup> model</h3></div>
<p class="item-cats"><span class="cat">MASH</span><span class="cat">Resmetirom</span><span class="cat">STAM</span></p>
<p class="item-desc"></p><p>As you may already know, the United States Food and Drug Administration (FDA) announced the approval of Rezdif…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/%e3%80%90hot-data%e3%80%91-resmetirom-mgl-3196-evaluation-data-available-in-stam-model/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.21</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">What is the best non-clinical liver cancer model with 100% cancer incidence rate and suitable for liver cancer assessment?</h3></div>
<p class="item-desc"></p><p>If you are considering a drug evaluation study for liver cancer using a mouse model, our STAMTM-HCC/IO+ model …</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/what-is-the-best-non-clinical-liver-cancer-model-with-100-cancer-incidence-rate-and-suitable-for-liver-cancer-assessment/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.19</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">[ Breaking News! ] First MASH treatment approved by FDA</h3></div>
<p class="item-desc"></p><p>On March 14th, industry-altering news was published. Do you know already what we are talking about? The United…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/breaking-news-first-mash-treatment-approved-by-fda/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">[Existing compounds] that have advanced to clinical trials will accelerate the launch of your drugs.</h3></div>
<p class="item-desc"></p><p>If you are planning to launch your therapeutic drug, you should select disease mouse models that have shown ac…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/existing-compounds-that-have-advanced-to-clinical-trials-will-accelerate-the-launch-of-your-drugs/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Pitfalls of [ disease model mice ] that researchers unknowingly fall into.</h3></div>
<p class="item-desc"></p><p>In order to evaluate your compound, rather than using a general pulmonary fibrosis model that does not match y…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/pitfalls-of-disease-model-mice-that-researchers-unknowingly-fall-into/"><span class="txt">READ MORE</span></a></p>
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<p class="item-date">2024.03.15</p>
<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">| A must for IPF researchers! | Suggestions for the best disease model for your research</h3></div>
<p class="item-desc"></p><p>If you are considering a drug efficacy study using a mouse model of lung fibrosis, you should use a model that…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/column/a-must-for-ipf-researchers-suggestions-for-the-best-disease-model-for-your-research/"><span class="txt">READ MORE</span></a></p>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Preclinical HCC study with positive control, Lenvatinib</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Enhance Research with Our Updated Model Lineup</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">CytoDyn has published a press release regarding the leronlimab efficacy preclinical study for MASH/fibrosis provided by SMC</h3></div>
<p class="item-desc"></p><p>CytoDyn Inc., which is our client, has announced the results of pharmacology study using a STAM™ mouse model. …</p>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Case study: Study published in Clinical and Translational Science on the effects of adiponectin-derived peptide ALY688 in MASH/liver fibrosis of STAM model.</h3></div>
<p class="item-desc"></p><p>We introduce a case study of pharmacology study of adiponectin-derived peptide ALY688 using our MASH model (ST…</p>
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<div class="item-ttl js-height" style=""><h3 class="ttl">Our clients’ presentations at AASLD ~The Liver Meeting 2024 ~</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Case study: Study published in Nature Biotechnology on the effects of TNIK inhibitor in lung and kidney fibrosis models.</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Preclinical HCC study with positive control, Lenvatinib</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Enhance Research with Our Updated Model Lineup</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">CytoDyn has published a press release regarding the leronlimab efficacy preclinical study for MASH/fibrosis provided by SMC</h3></div>
<p class="item-desc"></p><p>CytoDyn Inc., which is our client, has announced the results of pharmacology study using a STAM™ mouse model. …</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/news/cytodyn-has-published-a-press-release-regarding-the-leronlimab-efficacy-preclinical-study-for-mash-fibrosis-provided-by-smc/"><span class="txt">READ MORE</span></a></p>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Case study: Study published in Clinical and Translational Science on the effects of adiponectin-derived peptide ALY688 in MASH/liver fibrosis of STAM model.</h3></div>
<p class="item-desc"></p><p>We introduce a case study of pharmacology study of adiponectin-derived peptide ALY688 using our MASH model (ST…</p>
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<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/news/case-study-study-published-in-clinical-and-translational-science-on-the-effects-of-adiponectin-derived-peptide-aly688-in-mash-liver-fibrosis-of-stam-model/"><span class="txt">READ MORE</span></a></p>
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<div class="item-ttl js-height" style=""><h3 class="ttl">Our clients’ presentations at AASLD ~The Liver Meeting 2024 ~</h3></div>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Case study: Study published in Nature Biotechnology on the effects of TNIK inhibitor in lung and kidney fibrosis models.</h3></div>
<p class="item-desc"></p><p>We want to introduce a paper by Insilico Medicine, a company that focuses on fibrosis to develop drugs, and af…</p>
<p></p>
<p class="item-btn"><a class="c-btn01 smaler01" href="https://www.smccro-lab.com/news/case-study-study-published-in-nature-biotechnology-on-the-effects-of-tnik-inhibitor-in-lung-and-kidney-fibrosis-models/"><span class="txt">READ MORE</span></a></p>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Preclinical HCC study with positive control, Lenvatinib</h3></div>
<p class="item-desc"></p><p>We recently obtained new evaluation data on the Lenvatinib in our STAM model and it shows significantly improv…</p>
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<div class="item-ttl js-height" style="height: 97.1719px;"><h3 class="ttl">Enhance Research with Our Updated Model Lineup</h3></div>
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